Vascular and Endovascular Surgery Clinical Trials

Trials Accepting New Patients

AAA With Metformin (LIMIT) Trial. - Open to Enrollment 
In this research, the investigators are looking at the effects of a drug called metformin may have on the growth of abdominal aortic aneurysm (AAA)s. AAA is an abnormal enlargement of the aorta, which is the large artery in the abdomen (stomach area). The enlargement of the aorta carries a risk that it will rupture and cause life-threatening bleeding in the abdomen (belly). In this study the investigators hope to learn how metformin is associated with the enlargement or change in size of the AAA in study participants. Smaller studies have suggested that metformin may reduce the rate at which aortic aneurysms enlarge. This study will test this question: does metformin prevent AAAs from growing larger?

Lead Reseacher: Ronald Dalman, M.D.

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Complex EVAR

This clinical trial monitors the outcomes of complex endovascular aneurysm surgical repair techniques — including the “snorkel” and “chimney” techniques and others that use FDA-approved devices in different configurations — used to treat aortic aneurysms in challenging anatomical locations, including juxtarenal, thoracoabdominal, and arch/thoracic regions.

Lead researcher: Jason Lee, M.D.

Trials Not Currently Accepting New Patients

Analysis of Atherosclerotic Plaque Using Synchrotron X-Rays

This study uses a novel imaging technique, Synchrotron X-ray, to learn more about the physical characteristics and makeup of the plaque that builds up in the arteries in atherosclerosis.

Lead researcher: Jason Lee, M.D.

ENGAGE PAS

The Post Approval Study Evaluating the Long-Term Safety and Effectiveness of the Endurant Stent Graft System study, or ENGAGE PAS, tracks five-year outcomes for patient who have undergone endovascular repair of an aneurysm in the infrarenal or aortoiliac aorta with Endurant stent grafts.

Lead researcher: Ronald Dalman, M.D.

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GREAT Registry

This study will establish a registry of patients of patients who have had Gore medical devices implanted during endovascular aortic surgery to ensure that doctors have the best possible data on patient outcomes.

Lead researcher: Jason Lee, M.D.

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Gore Conformable AAA

This study evaluates how well the Gore Excluder Conformable AAA Endoprosthesis works to treat infrarenal aneurysms in the abdominal aorta.  

Lead researcher: Jason Lee, M.D.

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Zenith p-Branch

This study tests the use of the Zenith p-Branch graft in combination with Atrium iCAST covered stents to repair complex abdominal aortic aneurysms (AAAs) that are short-necked and/or juxtarenal.

Lead researcher: Jason Lee, M.D.

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Medtronic Valiant EVO  

This trial evaluates the effectiveness of the newest low-profile Valiant Evo Thoracic Stent Graft System to repair aneurysms in the descending thoracic aorta in patients who are candidates for endovascular repair.

Study lead: Jason Lee, M.D.

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Medtronic Endurant EVO

This clinical research study examines whether the Endurant Evo AAA stent graft system, installed via catheter to protect the weak aortic wall, offers effective treatment for abdominal aortic aneurysms.

Lead researcher: Jason Lee, M.D.

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PRESERVE

This trial analyzes how effectively the Zenith Branch Endovascular Graft-Iliac Bifurcation and the Atrium iCAST covered stent can seal aortoiliac or iliac aneurysms and assure pelvic blood flow.

Lead researcher: Jason Lee, M.D.

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TriVascular LEOPARD

This study collects data in order to compare the effectiveness of the AFX System as a treatment for abdominal aortic aneurysms (AAA) to that of other FDA-approved devices used to treat AAA.

Lead researcher: Jason Lee, M.D.

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TriVascular LUCY

This study tracks clinical outcomes for female patients who have had abdominal aortic aneurysms (AAAs) surgically treated with the Ovation Prime Abdominal Stent Graft System.

Lead researcher: Jason Lee, M.D.

For more information, click here.