Dalman Research Lab
Description
Dr. Dalman’s vascular lab uses a rodent model of abdominal aortic aneurysm created with porcine pancreatic elastase infusion to study the pathogenesis of aneurysmal disease. Of particular interest is the hemodynamics of aneurysmal disease and how flow modification alters the progression of the disease. In conjunction with several collaborators at Stanford University, we are also developing novel bio-cellular techniques to more closely follow aneurysmal progression on a microscopic level, including bioluminescence imaging, magnetic resonance cellular imaging, and PET/CT.
Funding
Dr. Dalman has a recently renewed RO-1 (R01 HL064338-05A2) entitled Mechano-biologic Determinants of AAA Disease with a budget period extending from 08/01/2005 - 06/30/2006, and a Project Period from 09/30/1999 through 06/30/2009.
Dr. Dalman is the Principal Investigator for an NIH funded research grant entitled AAA Disease: Mechanism, Stratification and Treatment. The study is called AAA: STOP, Abdominal Aortic Aneurysms: Simple Treatment Or Prevention. The study includes three related projects involving faculty in vascular biology, bioengineering, hematology, cardiology, proteomics, exercise physiology, biostatistics and bioinformatics. The objectives of AAA: STOP are to: 1) Characterize human AAA disease sufficiently to identify and validate novel biomarkers and imaging strategies for disease stratification, 2) Test the ability of exercise therapy to limit the growth of small AAAs, and 3) Investigate key molecular and cellular events present during experimental AAA evolution to identify and refine novel therapeutic strategies to suppress early disease. Please visit the AAA: STOP website for more information or view the listing on clinicaltrials.gov. You may also contact Julie White, Program Coordinator at Stanford for information about enrollment in this study at (650) 498-6039 or by e-mail .
Personnel
- Ronald L. Dalman, MD: Principal Investigator
- Noriyuki Miyama, MD, PhD: Postdoctoral Fellow
- Eiketsu Sho, MD, PhD: consultant
- Geoff Schultz, MD: Postdoctoral Fellow/general surgery resident
- Janice Yeung, MD: Postdoctoral Fellow/general surgery resident (University of Rochester)
- Monica Dua, MD: Postdoctoral Fellow/general surgery resident (UCSF East Bay)
Dalman Research Lab personnel from Left to Right: Maureen Tedesco, MD, Geoff Schultz, MD, Noriyuki Miyama, MD, PhD, & Tomoko Asagami, MD (not pictured are Eiketsu Sho, MD, PhD and Janice Yeung, MD)
